Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å
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چکیده
منابع مشابه
Crystal structure of an Okazaki fragment at 2-A resolution.
In DNA replication, Okazaki fragments are formed as double-stranded intermediates during synthesis of the lagging strand. They are composed of the growing DNA strand primed by RNA and the template strand. The DNA oligonucleotide d(GGGTATACGC) and the chimeric RNA-DNA oligonucleotide r(GCG)d(TATACCC) were combined to form a synthetic Okazaki fragment and its three-dimensional structure was deter...
متن کاملNeogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.
HFE2 (hemochromatosis type 2 gene) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin expression. Hepcidin is a central iron regulatory hormone predominantly secreted from hepatocytes. HJV also binds neogenin, a membrane protein wi...
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The structure of the nonaaquayttrium (III) bromate, [Y(H2O)9](BrO3)3, at low temperature (100 K) has been studied by means of single-crystal X-ray diffraction. Crystallography shows a hexagonal unit cell, space group P63/mmc (No. 194) with Z = 2, a = b = 11.7104(11) Å, c = 6.6259(5) Å and V = 786.90(12) Å3 at 100 K. The hydra...
متن کاملHemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
Hemojuvelin (HJV) is a coreceptor for bone morphogenetic protein (BMP) signaling that regulates hepcidin expression and iron metabolism. However, the precise combinations of BMP ligands and receptors used by HJV remain unknown. HJV has also been demonstrated to bind to neogenin, but it is not known whether this interaction has a role in regulating hepcidin expression. In the present study, we s...
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Legionella pneumophila RpoS (LpRpoS) is an alternative sigma factor of RNA polymerase 13 (RNAP) essential for virulence and stress resistance. To investigate the mechanism of RpoS in the 14 intracellular pathogen L. pneumophila, we determined the high-resolution crystal structure of the 15 LpRpoS (residues 95-194) containing a partial region 1.2 and region 2. The structure of LpRpoS 16 (residue...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2011
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2010.10.005